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Are Nanoparticles the New Hope for Diagnosing Melanoma?

By Enterprise Technology Review | Thursday, July 30, 2020

Nano-vaccine exceeds conventional methods of cancer treatment, including surgery, chemotherapy, radiation therapy, etc.

FREMONT, CA: One of the new cancer.net studies has shown that the majority of deaths this year alone are caused by skin cancer. Nanomedicine is the technology used for diagnosis and treatment, which is done by utilizing molecules of a size that is one-billionth of a meter. Such nanoparticles can be used to fight cancers, diseases, and illnesses, including cardiovascular disease, Aids, wounds, etc., irrespective of its very limited size. Cancer is a universal fight, and a range of different methods of treatment, including chemotherapy, radiation therapy, surgery, and immunotherapy, did not achieve the desired results. Nanomedicine has been used in recent times to treat the most severe skin cancers, including melanoma through increased diagnosis, disease prevention, and treatment.

In the event of shielding the skin from the high exposure to ultraviolet rays emitted by the sun, melanocytes will create more melanin pigment. It may induce invasive skin melanoma when synthesized uncontrollably. Scientists in Tel Aviv have recently developed a melanoma nano-vaccine. This vaccine improves the anti-cancer efficacy of tumor-inhibiting immunotherapy. The researchers utilize nanoparticles of 170 nanometers composed of a biodegradable polymer. The two peptide chains — HLA I and HLA II — who were expressed in melanoma cells were present in each particle. Infused nanoparticles activate the immune system by encouraging the immune cells to recognize melanoma cells and destroy them.

In the prevention and treatment, both primary tumors and diseases, the nano vaccine has been proved to be successful. The immune system of the body has learned to recognize and actively target melanoma cells. Two different responses are obtained when injected. The vaccine stopped the emergence of the virus in one case. In another, melanoma has been treated with vaccination and immunotherapy.

Though studied mainly on rodents, it has slowed the disease's development when it is used in humans and prolonged their lives. The new treatment offers a whole other way of treating melanoma effectively – even during the early stages of the disease, with the nano-vaccine approach.

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